Check out our product review of the best natural antidepressants. We tried 10 models and can tell you the absolute best varieties.
In Hurry? Checkout Our Top Pick Of Best Natural Antidepressants.
Our Top Pick
9.7/10 our score
Best Natural Antidepressants
Rank | Product Name | Score |
---|---|---|
1
![]() |
Only Doctor Designed Depression Pill, Enlifta Depression Supplement - Best Natural Antidepressant, 1 Month Supply,30 tablets.
|
9. 7
|
2
![]() |
Nutricost 5-HTP 100mg, 240 Capsules (5-Hydroxytryptophan) - Veggie Caps, Gluten Free, Non-GMO
|
9. 5
|
3
![]() |
Genius Joy - Serotonin Mood Booster for Anxiety Relief, Wellness & Brain Support, Nootropic Dopamine Stack w/Sam-e, Panax Ginseng & L-Theanine – Natural Anti Stress & Herbal Calm, 100 veggie pills
|
9. 1
|
4
![]() |
Natural Stacks Serotonin Supplement 60 ct. - Powerful Stress Relief and Mood Booster - for Men and Women - Brain Food Formula Enhances Serotonin Production
|
8. 8
|
5
![]() |
Ashwagandha 1300mg Made with Organic Ashwagandha Root Powder & Black Pepper Extract - 120 Capsules. 100% Pure Ashwagandha Supplement for Stress Relief, Anti-Anxiety & Adrenal, Mood & Thyroid Support
|
8. 6
|
6
![]() |
Joy-Filled | 100% Plant-Based Supplement for Anxiety & Depression Relief | Helps Relax The Mind, Boosts Mood, Relieve Stress | Contains 7 Powerful Herbs, Non-GMO, 60 Vegan Capsules
|
8. 2
|
7
![]() |
200 MG 5-HTP Plus Serotonin Synthesizers and Cofactor B6 for Improved Serotonin Conversion - Enhanced 5HTP Supplement for Serotonin Boost, Mood and Sleep Support
|
8. 0
|
8
![]() |
Mood Boost Support for Stress 1100mg - Positive Mood and Focus Support Supplement, Made in USA, Natural Serotonin & Dopamine Nootropic Pills with 5-HTP, Ashwagandha & GABA - 60 Capsules
|
7 .7
|
9
![]() |
Happy Pills Natural Anti Anxiety Relief & Depression Supplement | Dopamine Mood Boost, Serotonin Support, Relieve Stress, Calm Relaxation Enhancer, Best PMS Supplements, for Women & Men | 60 Capsules
|
7. 4
|
10
![]() |
St.John's Wort 900mg Supplement-Natural Antidepressant for Mood Boost, Anxiety & Depression Support-Provides Extended Stress Relief-120 capsules, 450mg of St Johns Wort with 0.3% Hypericin per Capsule
|
7. 2
|
1. Only Doctor Designed Depression Pill, Enlifta Depression Supplement - Best Natural Antidepressant, 1 Month Supply,30 tablets.
1
9.7/10 our score
Features
- NATURAL SAFE & EFFECTIVE ANTIDEPRESSANT FORMULA: More natural alternative to prescription drugs
- PSYCHIATRIST RECOMMENDED & FORUMLATED : Natural mood booster created by board certified psychiatrist
- CLINICALLY PROVEN: Contains Ideal Amounts of 5-HTP St John's Wort Folic Acid Rhodiola Root
- MADE IN USA at GMP certified facility so you know it is pure
- 100% MONEY BACK GUARANTEE: We know you will love Enlifta so we offer a No Questions Asked Guarantee
2. Nutricost 5-HTP 100mg, 240 Capsules (5-Hydroxytryptophan) - Veggie Caps, Gluten Free, Non-GMO
2
9.5/10 our score
Features
- 240 Vegetable Capsules of High Quality 5-HTP
- 100mg of 5-HTP Per Capsule
- Vegan Friendly, Non-GMO, Gluten Free
- 3rd Party Tested by ISO-Accredited Laboratories
- Made in a GMP Compliant, FDA Registered Facility. May Come With White or Blue Lid
3. Genius Joy - Serotonin Mood Booster for Anxiety Relief, Wellness & Brain Support, Nootropic Dopamine Stack w/Sam-e, Panax Ginseng & L-Theanine – Natural Anti Stress & Herbal Calm, 100 veggie pills
3
9.1/10 our score
Features
- LIFE HACK NOOTROPIC SEROTONIN BOOSTER - Formulated with SAM-e, rhodiola, ginseng and 11 more focus boosting vitamins and minerals for mood support and anxiety relief, Genius Joy was meant to a be a cheat code for finding yourself.
- FOCUS, ENERGY, WELLNESS, AND COGNITION -Replace antidepressants & clear brain fog with a more natural approach, professionals, athletes, gamers and everybody in-between can benefit from this serotonin booster.
- NATURAL DOPAMINE STACK WITH ANXIETY RELIEF - Getting a daily brain boost is great but anxiousness can undermine great nootropics. Without anxiety support, you'll be susceptible to the detriments that coincide with stress.*
- VITAMINS FOR STRESS RELIEF AND WELLNESS - Joy features a unique vitamin complex with b-12 and vitamin D, coupled with pure l-theanine to further reduce mental and physical while stabilizing mood. Joy has it all!
- HOLLISTIC APPROACH - Joy includes a handful of clinically backed aids for supporting mood, s-adenosylmethionine. 5-HTP and B-vitamins are key.
4. Natural Stacks Serotonin Supplement 60 ct. - Powerful Stress Relief and Mood Booster - for Men and Women - Brain Food Formula Enhances Serotonin Production
4
8.8/10 our score
Features
- HAPPY, CALM and CLEAR: Don’t let the daily grind get you down. Serotonin Brain Food contains the essential nutrients your body needs to make more of the “happy molecule”. It works within minutes to improve well-being, positivity and mood.
- DO MORE OF WHAT YOU LOVE: Stress stops us from being productive and living life to the fullest. Fight back and get motivated with Rhodiola Rosea, an adaptogenic herb and key ingredient in our formula. Rhodiola has been used for centuries and clinically studied to combat fatigue, reduce mental fatigue and stop burnout.
- POTENT and POWERFUL: The best of nature meets the best of science. We sourced the highest quality Rhodiola Rosea, L-Tryptophan, Vitamin B-3, Magnesium, and Zinc found on planet Earth. Our formula includes exact ratios of each ingredient found in scientific research. That’s why Serotonin Brain Food works fast and works well.
- RELIEF WHEN YOU NEED IT: It’s your life, go make the most out of it. Serotonin Brain Food contains the vitamins, minerals, herbs and adaptogens your body needs to produce serotonin on its own. It’s totally safe, non habit forming and fast acting. Boost your mood wherever you go and whenever it’s needed.
- NATURAL STACKS - #1 in BRAIN SUPPLEMENTS: Our formulas contain the finest natural ingredients, transparent open-source labeling and vigorous third-party testing to ensure purity and potency. Your purchase comes with a 100% happiness guarantee. If anything goes wrong, simply contact us and we’ll make it right.
5. Ashwagandha 1300mg Made with Organic Ashwagandha Root Powder & Black Pepper Extract - 120 Capsules. 100% Pure Ashwagandha Supplement for Stress Relief, Anti-Anxiety & Adrenal, Mood & Thyroid Support
5
8.6/10 our score
Features
- 1300mg - HIGHEST POTENCY FOR BEST ANTI-STRESS & ANTI-ANXIETY SUPPORT: Made with 100% organic ashwagandha root powder and organic black pepper extract for increased absorption, our pure ashwagandha capsules offers the most potent formula in the market (1300mg per serving) to deliver superior anti-stress, anti-anxiety and adrenal support*
- MADE WITH CERTIFIED ORGANIC ASHWAGANDHA ROOT POWDER: In order to ensure an ashwagandha supplement is truly organic, it must be certified by an accredited certifying agent. Made with organic ashwagandha extract, our natural ashwagandha supplement is certified organic by UDAF*
- SUPERIOR IMMUNE BOOST, HORMONAL BALANCE & MOOD SUPPORT: Because our ashwagandha powder is sourced from organic ashwagandha root, it delivers the optimum concentration of withanolides to stimulate adaptogenic activity and optimize adrenal health, stress relief and thyroid support. More potent than other ashwagandha supplements, ashwagandha oil and ashwagandha tincture, it combats adrenal fatigue and serves as a natural mood enhancer supplement*
- NO FILLERS - NO BINDERS - NO ALLERGENS - NO HEAVY METALS: Our ashwagandha root capsules are FREE of fillers, binders, nuts, eggs, shellfish and other common allergens. In addition, testing is performed after every critical stage of production to ensure our products are FREE of adulterants, solvent residues, aflatoxins, microbiological pathogens and heavy metals such as mercury*
- 100% MONEY BACK GUARANTEE: At NutriRise, we care about your experience. In fact we are so confident that you will love our Premium Ashwagandha that we back it with a 90-day money back guarantee. Our Ashwagandha Supplement is proudly manufactured in the USA. Each and every batch is independently and third-party tested for premium purity and potency*
6. Joy-Filled | 100% Plant-Based Supplement for Anxiety & Depression Relief | Helps Relax The Mind, Boosts Mood, Relieve Stress | Contains 7 Powerful Herbs, Non-GMO, 60 Vegan Capsules
6
8.2/10 our score
Features
- 100 PERCENT PLANT-BASED: Completely plant-based anxiety supplement and depression supplements that provides total mood support. Your brain and body may need a little extra nutritional support to help with anxiety, depression, and stress. We at Happy Healthy Hippie have found that absorbing very specific nutrients can be the key in getting your mind and body the relief that it needs, which is why we have created Joy-Filled.
- CONSISTS OF 7 POWERFUL HERBS: These 7 healing herbs have been used for centuries and are considered to be a mood enhancer that provides natural anxiety relief and act as a natural antidepressant. The dosage of each herb included has been scientifically proven to be effective. We do not believe in the concept of "fairy dusting", which is when a tiny amount of a herb or nutrient is included in a product, even though the dose is too small to be effective.
- ANXIETY RELIEF AND STRESS RELIEF: The herbs included help to increase the production of GABA, a key neurotransmitter that works to reduce restlessness and promote an overall calming effect. Other herbs such as Rhodiola Rosea and Gingko Biloba supports a healthy response to stress by decreasing the cortisol levels in your body and by calming the sympathetic nervous system.
- RELIEVES DEPRESSION AND BOOSTS MOOD: The collection of herbs works harmoniously together to act as an anti depressant and help you maintain a stable and positive mood. St Johns Wort works to increase the availability of the chemicals serotonin, dopamine, and norepinephrine in the brain, which are crucial components in maintaining a positive state of mind.
- CUSTOMER FRIENDLY: We truly appreciate each of you and are grateful to have you as customers. If our product doesn't meet your needs in the way you had hoped, we have a 60-day easy return policy. Our product is formulated and created in a FDA registered US facility that is certified under strict Good Manufacturing Practice standards by two certifying agencies.
7. 200 MG 5-HTP Plus Serotonin Synthesizers and Cofactor B6 for Improved Serotonin Conversion - Enhanced 5HTP Supplement for Serotonin Boost, Mood and Sleep Support
7
8/10 our score
Features
- 5-HTP ENHANCED SUPER FORMULA - We supplemented 200mg of pure 5-HTP with clinically proven serotonin synthesizers, SAMe and L Tryptophan. Tryptophan is metabolized into 5-HTP in the body, while SAMe is a well-known serotonin booster. In addition, both ingredients have been indicated to help 5-HTP conversion to serotonin, creating the ideal synergistic mood booster.
- B6 FOR IMPROVED SEROTONIN CONVERSION - Our formula includes a high dosage of Vitamin B6, the main co-factor necessary to convert 5-HTP into serotonin. Vitamin B6 has been clinically shown to aid 5-HTP conversion into serotonin, while even slight B6 deficiency can greatly inhibit the efficacy of 5-HTP.
- MOOD, ANXIETY & SLEEP SUPPORT - 5-HTP is the primary precursor to serotonin production in the body. Increased levels of serotonin have been scientifically shown to promote positive mood, anxiety relief and better sleep.
- DOCTOR-DRIVEN, SCIENCE BACKED - Bringing Dr. Emil’s unique knowledge as both a medical doctor & recognized authority in the supplementation field, our blends are painstakingly formulated to provide superior results and are always backed by science - free of gimmicks, fads & false promises.
- ONLY THE RIGHT STUFF - All Dr. Emil products are made from all-natural vitamins, minerals & herbal extracts, without the use of harmful additives, non-GMO, free of gluten and all top 8 allergens. All products are manufactured in the USA in a GMP certified laboratory.
8. Mood Boost Support for Stress 1100mg - Positive Mood and Focus Support Supplement, Made in USA, Natural Serotonin & Dopamine Nootropic Pills with 5-HTP, Ashwagandha & GABA - 60 Capsules
8
7.7/10 our score
Features
- ✔️ NATURAL MOOD SUPPORT: Our premium mood support blend has been expertly crafted with the highest quality natural herbs and ingredients to provide you with nutritional support for a calming, relaxed, and positive mood.
- ✔️ POWERFUL HERBAL BLEND: We have combined naturally soothing ingredients such as Ashwagandha, Chamomile, and St. Johns Wort, with essential vitamins and minerals - like Vitamin B-6, Vitamin B-12, and GABA, working together to provide long lasting daily mood and sleep support.
- ✔️ ENJOY EVERY MOMENT: It's easy to feel overwhelmed these days - this unique combination of vitamins, minerals, and herbs has been created to help you face your day with renewed confidence, and support a stable, positive mood and state of mind.
- ✔️ TRUSTED FORMULA: These Mood Support capsules are made in the USA following strict cGMP guidelines and tested in a third party lab. Vegan, Non-GMO all packed inside an easy to swallow vegetarian capsule.
- ✔️ RELATED: Mood Support for Stress 5 5htp ashagawanda ashwagandha best beta blockers calm capsules dopamine energy gaba genius good joy happy healthy herb herbs herbal htp improve increase labs libido life nutrition lift lifter male men mood natural new nootropics pill pills powder seratonin seritonin social serotonin sleep supplement supplements swings teens vegan vitamin vitamins women
9. Happy Pills Natural Anti Anxiety Relief & Depression Supplement | Dopamine Mood Boost, Serotonin Support, Relieve Stress, Calm Relaxation Enhancer, Best PMS Supplements, for Women & Men | 60 Capsules
9
7.4/10 our score
Features
- NATURAL ORGANIC NON-GMO PLANT-BASED HERBS: Plant-based anxiety supplement and depression supplements that provides total mood support. Your brain and body may need a little extra nutritional support to help with anxiety, depression, and stress. Absorbing very specific nutrients can be the key in getting your mind and body the relief that it needs.
- 7 POWERFUL ORGANIC HERBS: 7 healing herbs have been used for centuries and are considered to be a mood enhancer that provides natural anxiety relief and act as a natural antidepressant. These herbs are Gotu Kola Herb, Rhodiola Root, St. John's Wort Herb, Ashwagandha Root, Lemon Balm Leaf, Ginkgo Leaf, and Eleuthero Root. The dosage of each included herb has been scientifically proven to be effective.
- ANXIETY RELIEF AND STRESS RELIEF: The herbs included help increase the production of GABA, a key neurotransmitter that works to reduce restlessness and promote an overall calming effect. Other herbs such as Rhodiola Rosea and Gingko Biloba supports a healthy response to stress by decreasing the cortisol levels in your body and by calming the sympathetic nervous system.
- RELIEVES DEPRESSION & BOOSTS MOOD: The collection of herbs works harmoniously together to act as an anti depressant and help you maintain a stable and positive mood. St Johns Wort works to increase the availability of the chemicals serotonin, dopamine, and norepinephrine in the brain, which are crucial components in maintaining a feel good positive state of mind.
- YOUR HAPPINESS IS IMPORTANT: If our product doesn't meet your needs in the way you had hoped, we have a 100% Satisfaction Guarantee refund policy. Our product is made in the USA and manufactured in a GMP approved facility.
10. St.John's Wort 900mg Supplement-Natural Antidepressant for Mood Boost, Anxiety & Depression Support-Provides Extended Stress Relief-120 capsules, 450mg of St Johns Wort with 0.3% Hypericin per Capsule
10
7.2/10 our score
Features
- NATURAL MENTAL WELLNESS SUPPORT - for centuries, the flowering plant St. John's Wort was used as a health remedy in Europe. Today St. John's Wort is best known as a treatment for depression, anxiety and stress. St. John's Wort effective as prescribed antidepressants but with no side effects.
- EMOTIONAL WELLNESS - St. John’s Wort is a natural treatment for mental health problems. It contains 0.3% (2.7mg) of Hypericin per serving. Hypericin is the most important natural compound that increases the level of serotonin, hormone of happiness. St. John's Wort boosts mood, moderates Seasonal Affective Disorder (SAD), promotes a good night's sleep, relieves PMS symptoms and reduces menopausal symptoms.
- RECOMMENDED DOSE BY SCIENTIFIC STUDIES 900 MG - clinical trials evaluating the potency of St. John's Wort in depression have proved that the best results are achieved with 900 mg per day. Blossom Nature's 1 capsule of 450 mg taken twice a day provide the full clinical dose to relieve symptoms of depression and anxiety for 24 hours with No Side Effects.
- QUALITY and SAFETY - Blossom Nature's St. John’s Wort is Non-GMO, Vegan, Gluten Free. It is manufactured in GMP facility in the USA. Each bottle includes 120 capsules for a full 2 MONTH SUPPLY of highest quality St. John’s Wort.
- MONEY BACK GUARANTEE - 30 Days unconditional money back guarantee. We want you to be fully satisfied. If St. John’s Wort does not work for you, please send it back and get your money back.